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. 2014 Aug;97 Suppl 8:S50-5.

Neuroprotective Effects of Bacopa Monnieri (Brahmi) on Novel Object Recognition and NMDAR1 Immunodensity in the Prefrontal Cortex, Striatum and Hippocampus of Sub-Chronic Phencyclidine Rat Model of Schizophrenia

  • PMID: 25518293

Neuroprotective Effects of Bacopa Monnieri (Brahmi) on Novel Object Recognition and NMDAR1 Immunodensity in the Prefrontal Cortex, Striatum and Hippocampus of Sub-Chronic Phencyclidine Rat Model of Schizophrenia

Pritsana Piyabhan et al. J Med Assoc Thai. .

Abstract

Background: Cognitive impairment is a major problem, which eventually develops in schizophrenia. It contributes to the patients 'functional disability and cannot be attenuated by antipsychotic drugs. Bacopa monnieri (Brahmi), a neuroprotective herbal medicine in the elderly, might be a novel neuroprotective agent for prevention of cognitive deficit in schizophrenia.

Objective: To study neuroprotective effects ofBrahmi on novel object recognition task and cerebral glutamate/N-methyl-D- aspartate receptor subtype 1 (NMDAR1) immunodensity in sub-chronic phencyclidine (PCP) rat model ofschizophrenia.

Material and method: Rats were assigned to three groups; Group-A: Control, Group-B: PCP administration and Group- C: Brahmi + PCP. Discrimination ratio (DR) representing cognitive ability was obtainedfrom novel object recognition task. NMDAR1 immunodensity was measured in prefrontal cortex, striatum, cornu ammonis fields I (CA 1) and 2/3 (CA2/3) and dentate gyrus (DG) using immunohistochemistry.

Results: DR was significantly reduced in PCP group compared with control. This occurred alongside NMDAR1 up-regulation in CA2/3 and DG but not in prefrontal cortex, striatum or CA1. Brahmi + PCP group showed an increased DR score up to normal which occurred alongside a significantly decreased NMDARI immunodensity in CA2/3 and DG compared with PCP group.

Conclusion: Cognitive deficit observed in rats receiving PCP was mediated by NMDAR1 up-regulation in CA2/3 and DG Interestingly, receiving Brahmi before PCP administration can restore this cognitive deficit by decreasingNMDAR1 in these brain areas. Therefore, Brahmi could be a novel neuroprotective agentfor the prevention ofcognitive deficit in schizophrenia.

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