Mean lung pressure during adult high-frequency oscillatory ventilation: an experimental study using a lung model

Acta Med Okayama. 2014 Dec;68(6):323-9. doi: 10.18926/AMO/53021.


In adult high-frequency oscillatory ventilation (HFOV), stroke volume (SV) and mean lung pressure (PLung) are important for lung protection. We measured the airway pressure at the Y-piece and the lung pressure during HFOV using a lung model and HFOV ventilators for adults (R100 and 3100B). The lung model was made of a 20-liter, airtight rigid plastic container (adiabatic compliance: 19.3 ml/cmH2O) with or without a resistor (20 cmH2O/l/sec). The ventilator settings were as follows: mean airway pressure (MAP), 30 cmH2O; frequency, 5-15 Hz (every 1 Hz); airway pressure amplitude (AMP), maximum;and % of inspiratory time (IT), 50% for R100, 33% or 50% for 3100B. The measurements were also performed with an AMP of 2/3 or 1/3 maximum at 5, 10 and 15 Hz. The PLung and the measured MAP were not consistently identical to the setting MAP in either ventilator, and decreasing IT decreased the PLung in 3100B. In conclusion, we must pay attention to the possible discrepancy between the PLung and the setting MAP during adult HFOV.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Air Pressure*
  • Equipment Design
  • High-Frequency Ventilation / instrumentation*
  • High-Frequency Ventilation / methods*
  • Humans
  • Inhalation / physiology
  • Lung / physiology*
  • Models, Biological*
  • Models, Structural*
  • Respiration, Artificial / instrumentation
  • Respiration, Artificial / methods
  • Stroke Volume / physiology