The relation of SMI and the VSEP in a risk sample for neurodegenerative disorders

J Neural Transm (Vienna). 2015 Aug;122(8):1167-74. doi: 10.1007/s00702-014-1351-7. Epub 2014 Dec 18.


Vagus somatosensory evoked potentials (VSEP) have been shown to have higher latencies with aging, which are even more increased in patients with Alzheimer's disease and subjects with mild cognitive impairment compared to age-matched healthy controls. In this study, the association of VSEP with subjective memory impairment (SMI), a potential risk or prodromal marker for Alzheimer's disease, was examined. The association of VSEP latencies and SMI was studied in a healthy risk cohort, including 358 elderly subjects, who are in a longitudinal study of risk factors for neurodegenerative disorders. The results show increased VSEP latencies for peak P2 at Fz-F4 in subjects who report SMI and are worried about it as compared to subjects who report memory impairment, but are not concerned and subjects without complaints. The results support a potential role of VSEP for the detection of very early neurodegenerative processes which may precede Alzheimer's disease.

MeSH terms

  • Alzheimer Disease / diagnosis
  • Cognitive Dysfunction / diagnosis
  • Evoked Potentials, Somatosensory / drug effects
  • Evoked Potentials, Somatosensory / physiology*
  • Female
  • Humans
  • Male
  • Memory Disorders / drug therapy
  • Memory Disorders / physiopathology*
  • Middle Aged
  • Neurodegenerative Diseases / diagnosis
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / physiopathology*
  • Perception
  • Prospective Studies
  • Risk
  • Vagus Nerve / drug effects
  • Vagus Nerve / physiopathology*