Spatially gradated hydrogel platform as a 3D engineered tumor microenvironment

Adv Mater. 2015 Mar 4;27(9):1567-72. doi: 10.1002/adma.201404896. Epub 2014 Dec 17.


There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.

Keywords: glioblastoma; gradient; hydrogel; microfluidics; tumor microenvironment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials
  • Cell Count
  • Cell Line, Tumor
  • Gelatin
  • Gene Expression
  • Glioblastoma / metabolism
  • Glioblastoma / pathology
  • Humans
  • Hydrogels*
  • Microfluidics / methods
  • Tissue Engineering / methods*
  • Tumor Microenvironment*


  • Hydrogels
  • Gelatin