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. 2015 Feb;105(2):e10-6.
doi: 10.2105/AJPH.2014.302439.

Second-generation antipsychotics and tardive syndromes in affective illness: a public health problem with neuropsychiatric consequences

Frederick M Jacobsen  1
Affiliations

Second-generation antipsychotics and tardive syndromes in affective illness: a public health problem with neuropsychiatric consequences

Frederick M Jacobsen. Am J Public Health. 2015 Feb.

Abstract

Food and Drug Administration-approved information and public advertisements belie neurodegenerative risks for second-generation antipsychotics in affective illness. Package inserts label tardive syndromes "potentially reversible" while uniformly omitting patient counseling for long-term neurodegenerative side effects. I found that only 2 of 78 outpatients exposed to second-generation antipsychotics reported awareness of tardive syndromes. Updated literature challenges safety advantages of atypical versus typical antipsychotics. Physician and patient information regarding tardive syndromes from second-generation antipsychotics approved for affective illness is inadequate.

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