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Repurposing Drugs in Oncology (ReDO)-cimetidine as an Anti-Cancer Agent

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Repurposing Drugs in Oncology (ReDO)-cimetidine as an Anti-Cancer Agent

Pan Pantziarka et al. Ecancermedicalscience.

Abstract

Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types. These data are summarised and discussed in relation to a number of distinct mechanisms of action. Based on the evidence presented, it is proposed that cimetidine would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of cimetidine as an anti-cancer therapeutic is warranted. Furthermore, there is compelling evidence that cimetidine administration during the peri-operative period may provide a survival benefit in some cancers. A number of possible combinations with other drugs are discussed in the supplementary material accompanying this paper.

Keywords: ReDO project; cimetidine; drug repurposing; immunostimulant.

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References

    1. Sabesin SM. Safety issues relating to long-term treatment with histamine H2-receptor antagonists. Aliment Pharmacol Ther. 1993;7 Suppl 2:35–40. - PubMed
    1. Chandrasekhara KL, Iyer SK, Macchia RJ. Leucopenia and thrombocytopenia with cimetidine. J Natl Med Assoc. 1981;73(2):92–98. - PMC - PubMed
    1. Joint Formulary Committee. British National Formulary. 66. BMJ Group and Pharmaceutical Press; 2013.
    1. Bodemar G, Norlander B, Walan A. Pharmacokinetics of cimetidine after single doses and during continuous treatment. Clin Pharmacokinet. 1981;6(4):306–15. doi: 10.2165/00003088-198106040-00005. - DOI - PubMed
    1. Bodemar G, et al. The absorption of cimetidine before and during maintenance treatment with cimetidine and the influence of a meal on the absorption of cimetidine–studies in patients with peptic ulcer disease. Br J Clin Pharmacol. 1979;7(1):23–31. doi: 10.1111/j.1365-2125.1979.tb00892.x. - DOI - PMC - PubMed

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