Stimulatory effect of short-chain fatty acids on epithelial cell proliferation of isolated and denervated jejunal segment of the rat

Scand J Gastroenterol. 1989 Sep;24(7):886-90. doi: 10.3109/00365528909089230.


Involvement of the mesenteric nerve in the efferent transmission of the trophic effect of short-chain fatty acids was tested in rats. A short segment of jejunum was translocated under the skin with or without its mesenteric connection maintained. A mixture of acetic, propionic, and n-butyric acids (100, 20, and 60 mM, respectively) or 0.9% NaCl (control) was injected into the caecum via an ileostomy twice a day for 14 days. Trophic effects of short-chain fatty acids were observed in jejunal and caecal segments and in the translocated jejunal segments both with and without mesenteric connection. The results suggest that short-chain fatty acids given into the hindgut lumen can indirectly stimulate the epithelial cell proliferation of a distant intestinal segment without luminal continuation to the site of administration, and this trophic effect does not require efferent transmission by nerves in the mesentery. Blood-born mediation is likely.

MeSH terms

  • Acetates / administration & dosage
  • Animals
  • Butyrates / administration & dosage
  • Cecum / cytology
  • Cecum / drug effects
  • Cell Division / drug effects*
  • Denervation
  • Epithelial Cells
  • Epithelium / drug effects
  • Fatty Acids, Volatile / administration & dosage*
  • Ileostomy
  • Intestinal Mucosa / cytology
  • Intestinal Mucosa / drug effects*
  • Jejunum / cytology
  • Jejunum / drug effects*
  • Jejunum / transplantation
  • Male
  • Propionates / administration & dosage
  • Rats
  • Rats, Inbred F344
  • Splanchnic Nerves / physiology
  • Synaptic Transmission / drug effects


  • Acetates
  • Butyrates
  • Fatty Acids, Volatile
  • Propionates