Vitamin D influences asthmatic pathology through its action on diverse immunological pathways

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S314-21. doi: 10.1513/AnnalsATS.201405-204AW.

Abstract

The prevalence of vitamin D insufficiency and deficiency has increased markedly in recent decades to current epidemic levels (Hyppönen E, et al. Am J Clin Nutr 2007;85:860-868). In parallel, there has been an increase in the incidence of a range of immune-mediated conditions ranging from cancer to autoimmune and respiratory diseases, including chronic obstructive pulmonary disease and asthma (Holick MF. N Engl J Med 2007;357:266-281; Finklea et al. Adv Nutr 2011;2:244-253). There is also an association with increased respiratory infections, which are the most common cause of asthma exacerbations (Finklea et al. Adv Nutr 2011;2:244-253). Together, this has resulted in considerable interest in the therapeutic potential of vitamin D to prevent and improve treatment of asthma and other respiratory diseases. To this end, data from clinical trials involving supplementation with active vitamin D, or more commonly a precursor, are starting to emerge. This review considers mechanisms by which vitamin D may act on the immune system to dampen inappropriate inflammatory responses in the airway while also promoting tolerance and antimicrobial defense mechanisms that collectively maintain respiratory health.

Keywords: asthma; glucocorticoids; immune regulation; vitamin D.

Publication types

  • Review

MeSH terms

  • Asthma / etiology
  • Asthma / immunology*
  • Asthma / prevention & control
  • Humans
  • Immunity, Innate / drug effects*
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / drug therapy
  • Vitamin D Deficiency / immunology
  • Vitamins / therapeutic use

Substances

  • Vitamins
  • Vitamin D