Chest wall and rib irradiation and toxicities of early-stage lung cancer patients treated with CyberKnife stereotactic body radiotherapy

Future Oncol. 2014 Dec;10(15):2311-7. doi: 10.2217/fon.14.158.


Aim: The aim of the study is to evaluate the chest wall and rib toxicities in primary lung cancer patients treated with CyberKnife-based stereotactic body radiotherapy.

Materials & methods: In this study, data were collected from the 118 patients, of which 25 patients who had longer follow-up (mean: 21.9 months) were considered. Studied parameters were maximum point dose, doses to 1-100 cm(3) of chest wall and 1-10 cm(3) of ribs.

Results: Three patients developed chest wall pain (grade I). 25 studied patients, on average, received 27.7 Gy to 30 cm(3) of chest wall and 50.4 Gy to 1 cm(3) of rib. Nine patients had more than 30 Gy dose to 30 cm(3) of chest wall. No rib bone fracture was found.

Conclusion: No correlations of chest wall pain and volume of irradiation were found.

Keywords: CyberKnife; chest pain; chest wall toxicity; rib fracture; stereotactic body radiotherapy.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Incidence
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Pain, Postoperative / epidemiology
  • Pain, Postoperative / etiology
  • Radiation Dosage
  • Radiation Injuries / epidemiology*
  • Radiation Injuries / etiology
  • Radiosurgery / adverse effects*
  • Retrospective Studies
  • Ribs / pathology
  • Ribs / radiation effects
  • Thoracic Wall / pathology
  • Thoracic Wall / radiation effects