Microexons go big

Li Yang; Ling-Ling Chen

doi:10.1016/j.cell.2014.12.004

Microexons go big

Cell. 2014 Dec 18;159(7):1488-9. doi: 10.1016/j.cell.2014.12.004.

Authors

Li Yang¹, Ling-Ling Chen²

Affiliations

¹ Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology; CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: liyang@picb.ac.cn.
² State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China. Electronic address: linglingchen@sibcb.ac.cn.

PMID: 25525868
DOI: 10.1016/j.cell.2014.12.004

Abstract

Microexons are frequently underestimated in transcriptome analyses. Two studies published in Cell and Genome Research now independently report the identification of hundreds of microexons. Alternative splicing of some microexons is regulated by neuronal-specific RNA-binding proteins and modifies the function of proteins involved in neurogenesis, with misregulation linked to autism.

Publication types

Research Support, Non-U.S. Gov't