Abstract
We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Motifs
-
Fluorescence
-
Fluorescent Dyes*
-
Molecular Structure
-
Organophosphorus Compounds / chemical synthesis*
-
Organophosphorus Compounds / chemistry
-
Stilbenes / chemical synthesis*
-
Stilbenes / chemistry
-
alpha-Synuclein / analysis*
-
alpha-Synuclein / chemistry
Substances
-
Fluorescent Dyes
-
Organophosphorus Compounds
-
Stilbenes
-
alpha-Synuclein