Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder

Haematologica. 2015 Mar;100(3):300-7. doi: 10.3324/haematol.2013.091264. Epub 2014 Dec 19.


Episodic angioedema with eosinophilia (Gleich syndrome) is a rare disorder characterized by episodes of angioedema and eosinophilia that occur at monthly intervals and resolve spontaneously without therapy. Despite the striking periodicity of this disorder, its similarity to other cyclic hematopoietic disorders with multilineage involvement has not been assessed. To characterize the involvement of cell lineages in the etiology and pathogenesis of episodic angioedema with eosinophilia, four subjects were evaluated by blood counts and other analyses over the course of 1-2 months. Surface marker expression was assessed on T cells by flow cytometry and clonality by polymerase chain reaction. Intracellular cytokine evaluation, bone marrow and skin biopsies were performed during different parts of the cycle. Cycling of multiple cell lineages, including neutrophils, lymphocytes and eosinophils, was observed in the four subjects with the disorder with a periodicity of 25-35 days. An aberrant CD3(-)CD4(+) T-cell population was detected in all four subjects, and T-cell receptor rearrangement studies showed a clonal pattern in three subjects. A peak of type II cytokines was detected in the serum of subjects prior to the onset of symptoms and eosinophil cycling and corresponded to ex-vivo type II cytokines detected intracellularly in CD3(+)CD4(+)CD154(+) T cells. Although the etiology of episodic angioedema with eosinophilia is not yet known, multiple lineages, including lymphocytes, neutrophils and mast cells, are involved and may be related to disease pathogenesis. Whether these cells act directly or promote eosinophilia and eosinophil activation remains to be elucidated. All subjects gave informed consent and were evaluated under an Institutional Review Board-approved protocol (NCT00001406).

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adult
  • Angioedema / complications
  • Angioedema / diagnosis*
  • Angioedema / immunology
  • Angioedema / pathology
  • Antigens, CD / immunology
  • Bone Marrow / immunology
  • Bone Marrow / pathology
  • Cell Lineage / immunology*
  • Cytokines / immunology
  • Eosinophilia / complications
  • Eosinophilia / diagnosis*
  • Eosinophilia / immunology
  • Eosinophilia / pathology
  • Eosinophils / immunology
  • Eosinophils / pathology
  • Female
  • Gene Expression
  • Humans
  • Immunophenotyping
  • Male
  • Mast Cells / immunology
  • Mast Cells / pathology
  • Middle Aged
  • Neutrophils / immunology
  • Neutrophils / pathology
  • Periodicity
  • Skin / immunology
  • Skin / pathology
  • Syndrome
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology


  • Antigens, CD
  • Cytokines

Associated data

  • ClinicalTrials.gov/NCT00001406