Kruppel-like factors in muscle health and disease

Trends Cardiovasc Med. 2015 May;25(4):278-87. doi: 10.1016/j.tcm.2014.11.006. Epub 2014 Nov 15.


Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / metabolism*
  • Homeostasis*
  • Humans
  • Kruppel-Like Transcription Factors / genetics
  • Kruppel-Like Transcription Factors / metabolism*
  • Muscle, Skeletal / metabolism
  • Muscle, Smooth / metabolism
  • Myocardium / metabolism*
  • Up-Regulation


  • Kruppel-Like Transcription Factors