Intrinsically disordered proteins in cellular signalling and regulation

Nat Rev Mol Cell Biol. 2015 Jan;16(1):18-29. doi: 10.1038/nrm3920.


Intrinsically disordered proteins (IDPs) are important components of the cellular signalling machinery, allowing the same polypeptide to undertake different interactions with different consequences. IDPs are subject to combinatorial post-translational modifications and alternative splicing, adding complexity to regulatory networks and providing a mechanism for tissue-specific signalling. These proteins participate in the assembly of signalling complexes and in the dynamic self-assembly of membrane-less nuclear and cytoplasmic organelles. Experimental, computational and bioinformatic analyses combine to identify and characterize disordered regions of proteins, leading to a greater appreciation of their widespread roles in biological processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing / physiology*
  • Animals
  • Humans
  • Intrinsically Disordered Proteins / genetics
  • Intrinsically Disordered Proteins / metabolism*
  • Multiprotein Complexes / genetics
  • Multiprotein Complexes / metabolism
  • Organ Specificity / physiology
  • Protein Processing, Post-Translational / physiology*
  • Signal Transduction / physiology*


  • Intrinsically Disordered Proteins
  • Multiprotein Complexes