Theta sequences are essential for internally generated hippocampal firing fields

Nat Neurosci. 2015 Feb;18(2):282-8. doi: 10.1038/nn.3904. Epub 2014 Dec 22.

Abstract

Sensory cue inputs and memory-related internal brain activities govern the firing of hippocampal neurons, but which specific firing patterns are induced by either of the two processes remains unclear. We found that sensory cues guided the firing of neurons in rats on a timescale of seconds and supported the formation of spatial firing fields. Independently of the sensory inputs, the memory-related network activity coordinated the firing of neurons not only on a second-long timescale, but also on a millisecond-long timescale, and was dependent on medial septum inputs. We propose a network mechanism that might coordinate this internally generated firing. Overall, we suggest that two independent mechanisms support the formation of spatial firing fields in hippocampus, but only the internally organized system supports short-timescale sequential firing and episodic memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Cues*
  • GABA-A Receptor Agonists / administration & dosage
  • GABA-A Receptor Agonists / pharmacology
  • Hippocampus / cytology
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Male
  • Memory, Episodic*
  • Muscimol / administration & dosage
  • Muscimol / pharmacology
  • Nerve Net / drug effects
  • Nerve Net / physiology*
  • Neurons / physiology*
  • Periodicity
  • Rats, Long-Evans
  • Theta Rhythm / drug effects
  • Theta Rhythm / physiology*

Substances

  • GABA-A Receptor Agonists
  • Muscimol