Anti-tumor activities of triterpenes from Syzygium kusukusense

Nat Prod Commun. 2014 Nov;9(11):1557-8.

Abstract

In this study, we report the isolation from the stem of Syzygium kusukusense of five triterpenes, 2α-hydroxybetulinic acid (1), betulinic acid (2), platanic acid (3), ursolic acid (4), and hyptatic acid A (5). All were identified for the first time from this indigenous plant of Taiwan. Assessment of the cytotoxic activities of these compounds against a panel of human tumor cell lines, including MCF-7 breast, PC-3 prostate, and SCC2095 oral squamous cell cancers, revealed the high potency of compounds 1 (IC50, 5.7 - 7.6 μM) and, especially, 4 (IC50, 1.7 - 3.7 μM) in suppressing cell viability, which warrants further mechanistic investigations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents, Phytogenic
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Humans
  • Pentacyclic Triterpenes
  • Plant Stems / chemistry
  • Syzygium / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Pentacyclic Triterpenes
  • Triterpenes
  • betulinic acid
  • platanic acid
  • ursolic acid