Facile, protection-free, one-pot synthesis of aureusidin

Nat Prod Commun. 2014 Nov;9(11):1563-6.


A new, reliable, and convenient protection-free one-pot method for the synthesis of aureusidin (1) is described. The present synthetic approach involves the condensation of 4,6-dihydroxybenzofuranone with 3,4-dihydroxybenzaldehyde in the presence of concentrated HCl to afford aureusidin (1) in good yield with high purity. This procedure offers a short and simple route for the preparation of aureusidin (1), a bioactive natural product from several vegetal species, as well as for synthesis of other aurones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzaldehydes / chemistry
  • Benzofurans / chemical synthesis*
  • Benzofurans / chemistry*
  • Catechols / chemistry
  • Molecular Structure


  • Benzaldehydes
  • Benzofurans
  • Catechols
  • aurone
  • aureusidin
  • protocatechualdehyde