Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

doi:10.1016/j.ypmed.2014.12.014

. 2015 Mar:72:15-8.

doi: 10.1016/j.ypmed.2014.12.014. Epub 2014 Dec 19.

Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

Sean P Heffron¹, Caron B Rockman², Eugenia Gianos³, Yu Guo⁴, Jeffrey S Berger⁵

Affiliations

¹ Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: sean.heffron@nyumc.org.
² Department of Surgery, Division of Vascular Surgery, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: caron.rockman@nyumc.org.
³ Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: eugenia.gianos@nyumc.org.
⁴ Department of Population Health, Division of Biostatistics, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: yu.guo@nyumc.org.
⁵ Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA; Department of Surgery, Division of Vascular Surgery, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: jeffrey.berger@nyumc.org.

PMID: 25532677
PMCID: PMC4518851
DOI: 10.1016/j.ypmed.2014.12.014

Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

Sean P Heffron et al. Prev Med. 2015 Mar.

. 2015 Mar:72:15-8.

doi: 10.1016/j.ypmed.2014.12.014. Epub 2014 Dec 19.

Authors

Sean P Heffron¹, Caron B Rockman², Eugenia Gianos³, Yu Guo⁴, Jeffrey S Berger⁵

Affiliations

¹ Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: sean.heffron@nyumc.org.
² Department of Surgery, Division of Vascular Surgery, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: caron.rockman@nyumc.org.
³ Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: eugenia.gianos@nyumc.org.
⁴ Department of Population Health, Division of Biostatistics, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: yu.guo@nyumc.org.
⁵ Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA; Department of Surgery, Division of Vascular Surgery, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: jeffrey.berger@nyumc.org.

PMID: 25532677
PMCID: PMC4518851
DOI: 10.1016/j.ypmed.2014.12.014

Abstract

Nut consumption has been associated with lower risk of coronary heart disease and all-cause mortality. The association between nut intake and peripheral arterial disease (PAD) is uncertain.

Objective: We sought to investigate the association between nut consumption and presence of prevalent PAD in a large cross-sectional sample.

Methods: Self-referred participants at >20,000 US sites who completed a medical and lifestyle questionnaire were evaluated by screening ankle brachial indices for PAD. Multivariable logistic regression analysis was used to estimate odds of PAD in different nut consumption categories.

Results: Among 3,312,403 individuals, mean age was 63.6 ± 10.6 years and 62.8% were female. There were 219,527 cases of PAD. After multivariable adjustment there was an inverse association of nut intake with PAD. Compared to subjects with consumption of nuts<once/month, daily nut consumption was associated with a 21% (95% CI 20%-23%) lower odds of having PAD.

Conclusion: These observations suggest the need for more rigorous testing evaluating the role of nuts in PAD prevention.

Keywords: Nutrition; Nuts; Peripheral arterial disease.

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Conflict of interest statement

Conflicts of Interest Statement: The authors declare that there are no potential conflicts of interest.

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References

1. Bao Y, Han J, Hu FB, et al. Association of nut consumption with total and cause-specific mortality. N Engl J Med. 2013;369:2001–2011. doi: 10.1056/NEJMoa1307352. - DOI - PMC - PubMed
1. Berger JS, Hochman J, Lobach I, et al. Modifiable risk factor burden and the prevalence of peripheral artery disease in different vascular territories. J Vasc Surg. 2013;58:673–681. doi: 10.1016/j.jvs.2013.01. - DOI - PubMed
1. Brostow DP, Hirsch AT, Collins TC, Kurzer MS. The role of nutrition and body composition in peripheral arterial disease. Nat Rev Cardiol. 2012;9:634–643. doi: 10.1038/nrcardio.2012.117. - DOI - PMC - PubMed
1. Casas-Agustench P, Lopez-Uriarte P, Ros E, Bullo M, Salas-Salvado J. Nuts, hypertension and endothelial function. Nutr Metabl Cardiovasc Dis. 2011;21:S21–S33. doi: 10.1016/j.numecd.2011.01.009. - DOI - PubMed
1. Eckel RH, Jakicic JM, Ard JD, et al. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2014;63:2960–2984. doi: 10.1016/j.jacc.2013.11.003. - DOI - PubMed

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[1] Bao Y, Han J, Hu FB, et al. Association of nut consumption with total and cause-specific mortality. N Engl J Med. 2013;369:2001–2011. doi: 10.1056/NEJMoa1307352. - DOI - PMC - PubMed

[2] Bao Y, Han J, Hu FB, et al. Association of nut consumption with total and cause-specific mortality. N Engl J Med. 2013;369:2001–2011. doi: 10.1056/NEJMoa1307352. - DOI - PMC - PubMed

[3] Berger JS, Hochman J, Lobach I, et al. Modifiable risk factor burden and the prevalence of peripheral artery disease in different vascular territories. J Vasc Surg. 2013;58:673–681. doi: 10.1016/j.jvs.2013.01. - DOI - PubMed

[4] Berger JS, Hochman J, Lobach I, et al. Modifiable risk factor burden and the prevalence of peripheral artery disease in different vascular territories. J Vasc Surg. 2013;58:673–681. doi: 10.1016/j.jvs.2013.01. - DOI - PubMed

[5] Brostow DP, Hirsch AT, Collins TC, Kurzer MS. The role of nutrition and body composition in peripheral arterial disease. Nat Rev Cardiol. 2012;9:634–643. doi: 10.1038/nrcardio.2012.117. - DOI - PMC - PubMed

[6] Brostow DP, Hirsch AT, Collins TC, Kurzer MS. The role of nutrition and body composition in peripheral arterial disease. Nat Rev Cardiol. 2012;9:634–643. doi: 10.1038/nrcardio.2012.117. - DOI - PMC - PubMed

[7] Casas-Agustench P, Lopez-Uriarte P, Ros E, Bullo M, Salas-Salvado J. Nuts, hypertension and endothelial function. Nutr Metabl Cardiovasc Dis. 2011;21:S21–S33. doi: 10.1016/j.numecd.2011.01.009. - DOI - PubMed

[8] Casas-Agustench P, Lopez-Uriarte P, Ros E, Bullo M, Salas-Salvado J. Nuts, hypertension and endothelial function. Nutr Metabl Cardiovasc Dis. 2011;21:S21–S33. doi: 10.1016/j.numecd.2011.01.009. - DOI - PubMed

[9] Eckel RH, Jakicic JM, Ard JD, et al. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2014;63:2960–2984. doi: 10.1016/j.jacc.2013.11.003. - DOI - PubMed

[10] Eckel RH, Jakicic JM, Ard JD, et al. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2014;63:2960–2984. doi: 10.1016/j.jacc.2013.11.003. - DOI - PubMed

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Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

Affiliations

Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

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Abstract

Conflict of interest statement

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