A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors

Indrapal S Aidhen; Ramesh Mukkamala; Christopher Weidner; Sascha Sauer

doi:10.1021/ol503135u

A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors

Org Lett. 2015 Jan 16;17(2):194-7. doi: 10.1021/ol503135u. Epub 2014 Dec 23.

Authors

Indrapal S Aidhen¹, Ramesh Mukkamala, Christopher Weidner, Sascha Sauer

Affiliation

¹ Department of Chemistry, Indian Institute of Technology Madras , Chennai 600036, India.

PMID: 25534018
DOI: 10.1021/ol503135u

Abstract

A common building block for the synthesis of amorfrutin and cajaninstilbene acid derivatives has been developed. The library of synthesized compounds has enabled identification of new nontoxic ligands of peroxisome proliferator-activated receptors (PPAR) and potential inhibitors of the transcriptional corepressor protein NCoR. The biological data holds promise in identification of new potential leads for the antidiabetic drug discovery process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hypoglycemic Agents / chemical synthesis*
Hypoglycemic Agents / chemistry
Ligands
Molecular Structure
Peroxisome Proliferator-Activated Receptors / chemistry*
Peroxisome Proliferator-Activated Receptors / metabolism
Salicylates / chemical synthesis*
Salicylates / chemistry
Stilbenes / chemical synthesis*
Stilbenes / chemistry

Substances

3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid
Hypoglycemic Agents
Ligands
Peroxisome Proliferator-Activated Receptors
Salicylates
Stilbenes
amorfrutin A