Susceptibility of four species of small rodents to encephalomyocarditis (EMC) virus infection

Jikken Dobutsu. 1989 Oct;38(4):357-61. doi: 10.1538/expanim1978.38.4_357.

Abstract

The D variant of encephalomyocarditis virus (10(1)-10(5) PFU/head) was intraperitoneally inoculated into 4 species of small rodents, rats, mice, Syrian hamsters, and Mongolian gerbils, and the susceptibility of these animals to EMC virus was examined virologically and histopathologically 3 days after infection. Viral replication was detected in the brain (mice), in the heart (mice and gerbils), and in the pancreas (mice, hamsters, and gerbils). No viral replication was detected in rats. Histopathological changes were seen in the brain (mice and hamsters), in the heart (mice and gerbils), and in the pancreas (mice, hamsters, and gerbils). No histopathological changes were seen in rats. The present results suggest that it may be quite possible to produce EMC virus-induced diabetes mellitus not only in mice but also in hamsters and gerbils.

MeSH terms

  • Animals
  • Cricetinae
  • Diabetes Mellitus, Experimental / etiology
  • Disease Susceptibility
  • Encephalomyocarditis virus
  • Enterovirus Infections / etiology*
  • Enterovirus Infections / microbiology
  • Enterovirus Infections / pathology
  • Gerbillinae
  • Mesocricetus
  • Mice
  • Mice, Inbred Strains
  • Rats
  • Rats, Inbred Strains
  • Species Specificity
  • Virus Replication