Alteration of the Fetal Heart Rate Pattern Induced by the Use Of Clozapine during Pregnancy

Therapie. 2015 May-Jun;70(3):301-3. doi: 10.2515/therapie/2014214. Epub 2014 Dec 24.


Patients treated with clozapine show autonomic dysregulation and cardiac repolarisation changes. As clozapine crosses the placenta, it could have an impact on the fetus heart rate. We reported a case of reduction of the fetal heart rate variability in a patient treated with clozapine during her pregnancy. This anomaly disappeared with fetal maturation and it did not jeopardize the fetal well-being. This side effect had already been described and pharmacologists and obstetricians should be aware that clozapine may be responsible for these fetal heart rate alterations.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / adverse effects*
  • Clozapine / administration & dosage
  • Clozapine / adverse effects*
  • Female
  • Heart Rate, Fetal / drug effects*
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Schizophrenia / drug therapy


  • Antipsychotic Agents
  • Clozapine