Periodontitis: from microbial immune subversion to systemic inflammation

Nat Rev Immunol. 2015 Jan;15(1):30-44. doi: 10.1038/nri3785.


Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health. Recent studies have provided insights into the emergence and persistence of dysbiotic oral microbial communities that can mediate inflammatory pathology at local as well as distant sites. This Review discusses the mechanisms of microbial immune subversion that tip the balance from homeostasis to disease in oral or extra-oral sites.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antibiosis
  • Arthritis, Rheumatoid / etiology
  • Cardiovascular Diseases / etiology
  • Female
  • Humans
  • Immunity
  • Periodontitis / complications
  • Periodontitis / immunology*
  • Periodontitis / microbiology*
  • Pregnancy
  • Pregnancy Outcome
  • Respiratory Tract Diseases / etiology
  • Symbiosis