Corticosteroid action on choroid plexus: reduction in Na+-K+-ATPase activity, choline transport capacity, and rate of CSF formation

Exp Brain Res. 1989;77(3):605-10. doi: 10.1007/BF00249613.


Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated influence of glucocorticoids on these functions of the choroid plexus seem to be important components in their therapeutic effect on intracranial hypertension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Betamethasone / analogs & derivatives*
  • Betamethasone / pharmacology
  • Blood Glucose / metabolism
  • Cerebrospinal Fluid / metabolism*
  • Choline / pharmacokinetics*
  • Choroid Plexus / drug effects
  • Choroid Plexus / metabolism*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sodium-Potassium-Exchanging ATPase / metabolism*


  • Blood Glucose
  • betamethasone sodium phosphate
  • Betamethasone
  • Sodium-Potassium-Exchanging ATPase
  • Choline