Caprylic acid and glyceryl trinitrate combination for eradication of biofilm

Antimicrob Agents Chemother. 2015 Mar;59(3):1786-8. doi: 10.1128/AAC.04561-14. Epub 2014 Dec 22.


There is a growing need for biocompatible, broad-spectrum, nonantibiotic, antimicrobial treatments because of the frequent ineffectiveness of antibiotics against biofilms and the increasing incidence of antibiotic resistance. In this study, we demonstrate rapid and complete biofilm eradication in an in vitro model with synergistic combinations of glyceryl trinitrate and caprylic acid against resistant Gram-positive, Gram-negative, and fungal biofilms.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Biofilms / drug effects*
  • Caprylates / pharmacology*
  • Drug Resistance / drug effects
  • Drug Synergism
  • Drug Therapy, Combination / methods
  • Fungi / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Nitroglycerin / pharmacology*


  • Anti-Bacterial Agents
  • Caprylates
  • Nitroglycerin
  • octanoic acid