Transient expression of a Ca2+-activated Cl- current during development of quail sensory neurons

Dev Biol. 1989 Nov;136(1):129-39. doi: 10.1016/0012-1606(89)90136-x.


The expression of a calcium-activated chloride current (ICl(Ca)) was studied during the development of the sensory neurons of quail trigeminal ganglia. This current is expressed in 20% of the neurons by the 5th day of embryonic development; it can be found in nearly all neurons by the 7th day and subsequently disappears in half of them. Similar results were obtained with dorsal root ganglion neurons. The disappearance of ICl(Ca) in part of the sensory neurons during development is not due to a selective death of the neurons possessing this current and our results suggest that it is mediated by an interaction of the sensory neurons with their target tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / pharmacology*
  • Cell Survival
  • Cells, Cultured
  • Chloride Channels
  • Chlorides
  • Electric Conductivity
  • Ganglia, Sympathetic / cytology
  • Ganglia, Sympathetic / embryology
  • Membrane Proteins / physiology*
  • Neurons / physiology
  • Neurons, Afferent / physiology*
  • Quail / embryology*
  • Time Factors
  • Trigeminal Ganglion / cytology
  • Trigeminal Ganglion / embryology*


  • Chloride Channels
  • Chlorides
  • Membrane Proteins
  • Calcium