Ascending in utero herpes simplex virus infection in an initially healthy-appearing premature infant

Pediatr Dev Pathol. 2015 Mar-Apr;18(2):155-8. doi: 10.2350/14-09-1548-CR.1. Epub 2014 Dec 23.

Abstract

The usual route of acquisition for intrauterine herpes simplex virus (HSV) infection is transplacental. We evaluated a premature infant with in utero acquisition of HSV resulting from ascending infection. Histopathologic evidence of chronic chorioamnionitis and positive staining with immunohistochemistry for HSV in the placenta and umbilical cord established the diagnosis. The clinical presentation was also of interest in that the infant was initially healthy appearing.

Keywords: Ascending infection; chorioamnionitis; congenital infection; herpes simplex virus; in utero infection; intrauterine.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / therapeutic use
  • Antigens, Viral / analysis
  • Antiviral Agents / therapeutic use
  • Biopsy
  • Chorioamnionitis / diagnosis
  • Chorioamnionitis / drug therapy
  • Chorioamnionitis / virology*
  • Female
  • Gestational Age
  • Herpes Simplex / diagnosis
  • Herpes Simplex / drug therapy
  • Herpes Simplex / transmission*
  • Herpes Simplex / virology
  • Humans
  • Immunohistochemistry
  • Infant, Newborn
  • Infant, Premature*
  • Infectious Disease Transmission, Vertical*
  • Male
  • Placenta / virology
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Complications, Infectious / virology*
  • Simplexvirus / immunology
  • Simplexvirus / pathogenicity*
  • Umbilical Cord / virology
  • Young Adult

Substances

  • Antigens, Viral
  • Antiviral Agents
  • Acyclovir