Analysis of risk factors for chronic obstructive pulmonary disease in clean-up workers of the Chornobyl accident

Probl Radiac Med Radiobiol. 2014 Sep;19:345-51.
[Article in En, Ukrainian]

Abstract
in En , Ukrainian

Objective. To analyze the effects of ionizing exposure, age and smoking on the development of chronic non-specific lung disease in a cohort of liquidators of the Chornobyl consequences included in the Clinical and Epidemiological Registry SI "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine". Materials and methods. The analysis included data on 7156 of the Chornobyl liquidators, of which 6 257 (87.4 %) men and 899 (12.6 %) women who were examined between 1993 and 2010 by pulmonologist. Results. Chronic bronchopulmonary diseases were detected in 50.0 % of the surveyed persons. The overall exposure dose was significantly higher among liquidators, which developed bronchopulmonary diseases (24.29 ± 0.82 sSv) compared with those without bronchopulmonary disease (14.58 ± 0.62 sSv), p = 0.001. In smokers the incidence of chronic obstructive pulmonary disease was twice higher than in those who did not smoke (10.2 and 5.16 %, respectively, p = 0.0001). Conclusion. The negative effect of ionizing radiation amplified by other risk factors for chronic bronchopulmonary disease: association between exposure doses and somatic pathology manifested in the surveyed people over the age of 45 years; at the same exposure dose risk of bronchopulmonary diseases was higher for smokers.

Meta. Provesty analiz vplyvu ionizujuchogo vyprominjuvannja, viku ta kurinnja na rozvytok hronichnyh nespecyfichnyh zahvorjuvan' legen' v kogorti uchasnykiv likvidacii' naslidkiv avarii' na ChAES (ULNA), vkljuchenyh do Kliniko-epidemiologichnogo rejestru DU “Nacional'nyj naukovyj centr radiacijnoi' medycyny Nacional'noi' akademii' medychnyh nauk Ukrai'ny”. Materialy ta metody. Do analizu uvijshly dani na 7156 ULNA, z nyh 6 257 (87,4 %) cholovikiv ta 899 (12,6 %) zhinok, jakyh bulo obstezheno u period z 1993 po 2010 roky ta ogljanuto pul'monologom. Rezul'taty. Hronichni zahvorjuvannja bronholegenevoi' systemy vyjavleni u 50,0 % obstezhenyh osib. Doza oprominennja bula virogidno vyshhoju sered uchasnykiv LNA, v jakyh rozvynulys' zahvorjuvannja bronholegenevoi' systemy (24,29 ± 0,82 sZv), porivnjano z osobamy bez bronholegenevoi' patologii' (14,58 ± 0,62 sZv), p = 0,001. U kurciv chastota vyjavlennja hronichnogo obstruktyvnogo zahvorjuvannja legen' bula vdvichi vyshhoju, nizh u tyh, hto ne kuryv (10,2 ta 5,16 %, vidpovidno, r = 0,0001). Vysnovky. Negatyvnyj vplyv ionizujuchogo vyprominjuvannja posyljuvavsja inshymy faktoramy ryzyku rozvytku hronichnyh bronholegenevyh zahvorjuvan': asociacija mizh dozovym navantazhennjam ta somatychnoju patologijeju projavljalas' u obstezhenyh osib u vici starshe 45 rokiv; pry odnakovij dozi oprominennja ryzyk rozvytku zahvorjuvan' bronholegenevoi' systemy buv vyshhym u kurciv.

Keywords: Chornobyl NPP accident; chronic obstructive pulmonary disease; inhalation impact of radionuclide; ionizing exposure; risk factors.