Evaluation of Anti-Inflammatory and Analgesic Activities and the Phytochemical Study of Astragalus Arbusculinus Gum in Animal Models

J Basic Clin Physiol Pharmacol. 2015 Jul;26(4):369-74. doi: 10.1515/jbcpp-2014-0092.

Abstract

Background: The importance of inflammatory diseases and side effects of conventional drugs necessitate the finding of new anti-inflammatory agents from natural sources. In this study, for the first time, the anti-inflammatory and analgesic effects of the aqueous extract of Astragalus arbusculinus gum were evaluated in animal models.

Methods: Thirty-five male Wistar rats were divided into five groups and pretreated with different doses of A. arbusculinus gum extract before the injection of formalin. Paw edema was measured by a plethysmometer at time 0 and after 8 days and compared to controls. The analgesic effect of the extract was evaluated using the hot-plate test in 42 male albino mice.

Results: The extract of A. arbusculinus gum decreased the rat paw edema in a dose-dependent manner. The effect on inflammation of the highest dose of extract was comparable to sodium salicylate. Astragalus arbusculinus gum extract at doses of 300 and 1000 mg/kg showed analgesic effects comparable to sodium salicylate and morphine, respectively. A preliminary phytochemical study and the determination of the total phenolic content of the gum extract were performed for the first time.

Conclusions: The aqueous extract of A. arbusculinus gum reduced the inflammation and pain in a dose-dependent manner and is a good candidate for further studies of safety and efficacy. The clarification of active components of the plant is necessary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Astragalus Plant*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Inflammation / drug therapy
  • Male
  • Mice
  • Pain / drug therapy*
  • Plant Extracts / pharmacology*
  • Plant Gums
  • Plant Leaves
  • Rats
  • Rats, Wistar
  • Sodium Salicylate / pharmacology

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Plant Gums
  • Sodium Salicylate