[The ultrastructural organization of the liver of rats with experimental hepatitis after drinking mineral water containing humic acids]

Vopr Kurortol Fizioter Lech Fiz Kult. 2014 Sep-Oct:(5):35-41.
[Article in Russian]


We undertook the ultrastructural analysis of liver parenchyma taken from male rats with experimental hepatitis induced by the administration of paracetamol at a dose of 1000 mg per 1 kg body weight either following a course of drinking mineral water containing humic acids at a concentration of 20 mg/sq. decimeter) or 14 days after the termination of the drug action (the after-effect phase). It was shown that the consumption of mineral water during 21 days resulted in the modification of the ultrastructural organization of hepatocytes apparent as the increased amount of cisterns in the granulosa endoplasmic system, glycogen rosettes, and mitochondrial polymorphism. These changes give evidence of the restoration of the energy, glycogen and protein synthesizing functions disturbed by paracetamol administration. The after-effect phase was characterized by the further strengthening of reparative processes and the functional activity of hepatic cells.

MeSH terms

  • Acetaminophen / pharmacokinetics
  • Acetaminophen / toxicity
  • Animals
  • Chemical and Drug Induced Liver Injury / metabolism
  • Chemical and Drug Induced Liver Injury / pathology
  • Chemical and Drug Induced Liver Injury / prevention & control*
  • Energy Metabolism / drug effects
  • Free Radicals / metabolism
  • Hepatitis, Animal / metabolism
  • Hepatitis, Animal / pathology
  • Hepatitis, Animal / prevention & control*
  • Hepatocytes / drug effects
  • Hepatocytes / metabolism
  • Hepatocytes / ultrastructure
  • Humic Substances*
  • Lipid Peroxidation
  • Liver / drug effects
  • Liver / metabolism
  • Liver / ultrastructure*
  • Male
  • Mineral Waters / administration & dosage
  • Mineral Waters / analysis
  • Mineral Waters / therapeutic use*
  • Rats


  • Free Radicals
  • Humic Substances
  • Mineral Waters
  • Acetaminophen