Serum autotaxin levels correlate with hepatic dysfunction and severity in postoperative biliary atresia

Biomarkers. 2015 Feb;20(1):89-94. doi: 10.3109/1354750X.2014.994564. Epub 2014 Dec 24.


Objective: To investigate correlation of serum autotaxin and disease severity in biliary atresia (BA).

Methods: Eighty postoperative BA patients and 15 controls were recruited. Serum autotaxin levels were determined by enzyme-linked immunosorbent assay.

Results: BA patients had greater serum autotaxin and liver stiffness than controls. Serum autotaxin and liver stiffness were markedly elevated in BA patients with jaundice compared to those without jaundice. Furthermore, serum autotaxin was correlated with liver stiffness and biochemical parameters in BA.

Conclusions: Elevated serum autotaxin was correlated with hepatic dysfunction in BA. Accordingly, serum autotaxin is a promising biomarker reflecting the severity in BA.

Keywords: Autotaxin; biliary atresia; jaundice; liver stiffness; severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Aspartate Aminotransferases / blood
  • Biliary Atresia / blood*
  • Biliary Atresia / pathology
  • Biliary Atresia / surgery
  • Bilirubin / blood
  • Biomarkers / blood
  • Case-Control Studies
  • Child
  • Female
  • Humans
  • Liver / physiopathology
  • Male
  • Phosphoric Diester Hydrolases / blood*
  • Postoperative Period


  • Biomarkers
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Phosphoric Diester Hydrolases
  • alkylglycerophosphoethanolamine phosphodiesterase
  • Bilirubin