Is signal peptide-CUB-EGF domain-containing protein1 a diagnostic biomarker in patients with hypertensive crises

Clin Hemorheol Microcirc. 2015;61(3):513-22. doi: 10.3233/CH-141917.


Background: Platelet activation might play a significant role in the pathophysiology of cardiovascular and cerebrovascular events in hypertension (HT). Signal peptide-CUB-EGF domain-containing protein1 (SCUBE1), an indicator of platelet activation, is increased in HT. The aim of this study was to investigate the SCUBE1 in patients with hypertensive crises.

Methods: This study included 33 hypertensive urgency (HU) and 39 hypertensive emergency (HI) patients admitted to our emergency department with a diagnosis of hypertensive crisis. Platelet activation was evaluated with biochemical markers such as SCUBE1, soluble CD40L (sCD40L), mean platelet volume, and platelet count.

Results: The SCUBE1 values of the HE patients were significantly higher than other groups (1.09 ± 0.49, 0.71 ± 0.23 and 0.37 ± 0.02 ng/dl, respectively; p < 0.01). The sCD40L values were higher in the hypertensive crises compared with the control group (4.16 ± 1.82, 3.41 ± 1.76 and 1.76 ± 0.68 ng/ml, respectively; p < 0.01). More importantly, SCUBE1 had high sensitivity and specificity in the detection of target organ damage.

Conclusion: In present study showed that SCUBE1 was significantly higher in HE patients. In addition, sCD40L level, presence of diabetes, and systolic blood pressure were independently associated with increased SCUBE1. According to our results, SCUBE1 might be a diagnostic biomarker in hypertensive crisis patients.

Keywords: Hypertensive crises; mean platelet volume; signal peptide-CUB-EGF domain-containing protein1; soluble CD40 ligand; target organ damage.

MeSH terms

  • Aged
  • Biomarkers / blood*
  • Epidermal Growth Factor / metabolism*
  • Female
  • Humans
  • Hypertension / blood*
  • Male
  • Mean Platelet Volume / methods*
  • Middle Aged
  • Platelet Activation / physiology
  • Protein Sorting Signals


  • Biomarkers
  • Protein Sorting Signals
  • Epidermal Growth Factor