Neonatal antibody-dependent cellular cytotoxic antibody levels are associated with the clinical presentation of neonatal herpes simplex virus infection

J Infect Dis. 1989 Nov;160(5):770-6. doi: 10.1093/infdis/160.5.770.


The role of antiviral antibodies in protection against neonatal herpes simplex virus (HSV) infection remains controversial. The relationship between neonatal and maternal anti-HSV antibodies and disease presentation was analyzed in 47 babies. Of the neonates, 77% had localized and 23% had disseminated HSV infection. Antibody-dependent cellular cytotoxic (ADCC) antibodies were evaluated in comparison with HSV neutralizing antibodies. High maternal (greater than 1:10(4)) or neonatal (greater than 1:10(3)) anti-HSV ADCC antibody levels or high neonatal antiviral neutralizing levels (greater than 1:20) were independently associated with an absence of disseminated HSV infection. Cochran-Mantel-Haenszel analysis demonstrated that ADCC levels were associated with disease status (P less than .02) while controlling for the level of neutralizing antibody.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Viral / immunology*
  • Antibody-Dependent Cell Cytotoxicity / immunology*
  • Encephalitis / complications
  • Female
  • Herpes Simplex / immunology*
  • Humans
  • Infant, Newborn / immunology*
  • Infant, Newborn, Diseases / immunology*
  • Pregnancy
  • Pregnancy Complications, Infectious / immunology
  • Simplexvirus / immunology


  • Antibodies, Viral