Myeloid-derived suppressor cells as therapeutic target in hematological malignancies

Front Oncol. 2014 Dec 8:4:349. doi: 10.3389/fonc.2014.00349. eCollection 2014.


Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that accumulate during pathological conditions such as cancer and are associated with a poor clinical outcome. MDSC expansion hampers the host anti-tumor immune response by inhibition of T cell proliferation, cytokine secretion, and recruitment of regulatory T cells. In addition, MDSC exert non-immunological functions including the promotion of angiogenesis, tumor invasion, and metastasis. Recent years, MDSC are considered as a potential target in solid tumors and hematological malignancies to enhance the effects of currently used immune modulating agents. This review focuses on the characteristics, distribution, functions, cell-cell interactions, and targeting of MDSC in hematological malignancies including multiple myeloma, lymphoma, and leukemia.

Keywords: hematological malignancies; immune system; leukemia; lymphoma; multiple myeloma; myeloid-derived suppressor cells; stem cell transplantations.

Publication types

  • Review