Exploring Systems Affected by the Heat Shock Response in Plasmodium Falciparum via Protein Association Networks

Int J Comput Biol Drug Des. 2014;7(4):369-83. doi: 10.1504/IJCBDD.2014.066554. Epub 2014 Dec 25.

Abstract

The heat shock response is a general mechanism by which organisms deal with physical insults such as sudden changes in temperature, osmotic and oxidative stresses, and exposure to toxic substances. Plasmodium falciparum is exposed to drastic temperature changes as a part of its life cycle and maintains an extensive repertoire of heat shock response-related proteins. As these proteins serve to maintain the parasite in the face of anti-malarial drugs as well, better understanding of the heat shock-related systems in the malaria parasite will lead to therapeutic approaches that frustrate these systems, leading to more effective use of anti-malarials. Here we use protein association networks to broaden our understanding of the systems impacted by and/or implicated in the heat shock response.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Computer Simulation
  • Heat-Shock Proteins / metabolism*
  • Heat-Shock Response / physiology*
  • Models, Biological*
  • Plasmodium falciparum / physiology*
  • Protein Interaction Mapping / methods
  • Protozoan Proteins / metabolism*
  • Signal Transduction / physiology*

Substances

  • Heat-Shock Proteins
  • Protozoan Proteins