Effects of B-type natriuretic peptide on cardiovascular biomarkers in healthy volunteers

J Appl Physiol (1985). 2015 Feb 15;118(4):395-9. doi: 10.1152/japplphysiol.00101.2014. Epub 2014 Dec 24.


Cardiovascular biomarkers provide independent prognostic information in the assessment of mortality and cardiovascular complications. However, little is known about possible interactions between these biomarkers. In the present study, we evaluated the influence of B-type natriuretic peptide (BNP) on midregional-proadrenomedullin (MR-proADM), C-terminal-proendothelin-1 (CT-proET-1), growth differentiation factor-15 (GDF-15), midregional-proatrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin in healthy volunteers. Ten healthy male subjects (mean age 24 yr) participating in a randomized, placebo-controlled, single-blinded crossover study received placebo or 3.0 pmol·kg(-1)·min(-1) human BNP 32 during a continuous infusion lasting for 4 h. Effects of BNP on other cardiovascular biomarkers were assessed. BNP did not change concentrations of MR-proADM, copeptin, CT-proET1, GDF-15, or procalcitonin. In contrast, MR-proANP was significantly decreased during BNP infusion. BNP as an established cardiovascular biomarker did not affect plasma concentrations of other cardiovascular biomarkers in a model of healthy volunteers.

Keywords: BNP; cardiovascular biomarkers; healthy volunteers; multimarker approaches.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenomedullin / metabolism
  • Adult
  • Atrial Natriuretic Factor / metabolism
  • Biomarkers / metabolism*
  • Calcitonin / metabolism
  • Calcitonin Gene-Related Peptide
  • Cardiovascular System / metabolism*
  • Cross-Over Studies
  • Endothelin-1 / metabolism
  • Glycopeptides / metabolism
  • Growth Differentiation Factor 15 / metabolism
  • Healthy Volunteers
  • Humans
  • Male
  • Natriuretic Peptide, Brain / metabolism*
  • Peptide Fragments / metabolism
  • Protein Precursors / metabolism
  • Young Adult


  • Biomarkers
  • CALCA protein, human
  • Endothelin-1
  • GDF15 protein, human
  • Glycopeptides
  • Growth Differentiation Factor 15
  • Peptide Fragments
  • Protein Precursors
  • copeptins
  • mid-regional pro-adrenomedullin, human
  • midregional pro-atrial natriuretic peptide, human
  • proendothelin 1
  • Natriuretic Peptide, Brain
  • Adrenomedullin
  • Atrial Natriuretic Factor
  • Calcitonin
  • Calcitonin Gene-Related Peptide