Outcomes of bronchial artery embolization for life-threatening hemoptysis secondary to tuberculosis

PLoS One. 2014 Dec 26;9(12):e115956. doi: 10.1371/journal.pone.0115956. eCollection 2014.

Abstract

Objective: To appraise the immediate and long-term outcomes of bronchial arterial embolization for life-threatening hemoptysis secondary to tuberculosis.

Methods: 112 patients with life-threatening hemoptysis due to tuberculosis underwent bronchial artery embolization from January 2004 to February 2014. Life-threatening hemoptysis was defined as expectoration of at least 400 ml of blood in 24 hour. The median follow-up is 20 months, ranging from 2 to 52 months.

Results: The hemoptysis control rate was 86.6% at 14 days, 84.8% at 30 days, 78.6% at 240 days, 75.9% at 360 days, respectively. None of these characteristics, including gender, age and tuberculosis status, was significantly associated with immediate control of bleeding. Patients with active tuberculosis had a significantly longer recurrence-free duration than did patients with inactive tuberculosis (P = 0.040), which was further confirmed by Cox regression hazards model (P = 0.046). There was no spinal cord complication or mortality related to bronchial artery embolization. The most common complication was transient chest pain.

Conclusion: Bronchial arterial embolization is an effective and safe technique in the management of life-threatening hemoptysis secondary to tuberculosis. Active tuberculosis may be associated with a lower rate of recurrence of hemoptysis.

MeSH terms

  • Bronchial Arteries* / pathology
  • Embolization, Therapeutic* / adverse effects
  • Embolization, Therapeutic* / methods
  • Female
  • Follow-Up Studies
  • Hemoptysis / complications*
  • Hemoptysis / therapy*
  • Humans
  • Lung / blood supply
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Retrospective Studies
  • Treatment Outcome
  • Tuberculosis / complications*

Grants and funding

The authors have no support or funding to report.