Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study

Jing Liu; Xiaobo Wang; Yangwu Ren; Xuelian Li; Xichen Zhang; Baosen Zhou

doi:10.1371/journal.pone.0115845

Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study

PLoS One. 2014 Dec 26;9(12):e115845. doi: 10.1371/journal.pone.0115845. eCollection 2014.

Authors

Jing Liu¹, Xiaobo Wang¹, Yangwu Ren², Xuelian Li², Xichen Zhang², Baosen Zhou²

Affiliations

¹ Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China; Clinical Medicine of Seven System, China Medical University, Shenyang, China.
² Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.

Abstract

Background: Accumulated evidence has indicated that ataxia-telangiectasia mutated (ATM) gene polymorphisms are closely related to lung cancer. We aimed to explore the prognostic value of rs189037 (G>A), one of ATM single nucleotide polymorphisms (SNPs), and detect whether it involves in the risk of lung cancer in Chinese Han people.

Methods: In this hospital-based matched case-control study, 852 lung cancer patients and 852 healthy controls have been put into comparison to analyze the association between rs189037 and lung cancer risk in Chinese. The single nucleotide polymorphisms were determined by TaqMan real-time PCR and we used SPSS software to perform the statistical analyses.

Results: Individuals carrying variant AA genotype of rs189037 had higher lung cancer risk (adjusted OR: 1.56) than those carrying GG genotype. After analyzing data respectively from different groups divided by genders and smoking status, we observed that the risk effect of AA genotype on the lung cancer was significant in females, non-smokers and female non-smokers, as well as the risk effect of GA genotype in male smokers. Compared with non-smokers carrying GG genotype, smokers carrying at least one A allele had higher risk of developing lung cancer than those with GG genotype (adjusted OR: 3.52 vs. adjusted OR: 2.53).

Conclusions: This study suggested that rs189037 (G>A) polymorphism is associated with lung cancer risk in Chinese Han population. AA genotype and A allele may be dangerous lung cancer signals in Chinese and make contribution to diagnostic and treatment value.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Ataxia Telangiectasia / genetics*
Case-Control Studies
China / epidemiology
Female
Genetic Predisposition to Disease
Genotype
Humans
Lung / pathology
Lung Neoplasms / diagnosis
Lung Neoplasms / epidemiology
Lung Neoplasms / genetics*
Male
Polymorphism, Single Nucleotide*
Risk Factors
Smoking / adverse effects

Grants and funding

This study was supported by grant no. 81272293 from National Natural Science Foundation of China; BZ received the funding. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.