A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene

Oncogene. 1989 Nov;4(11):1281-4.


Avian sarcoma virus 1 (ASV-1) was isolated from a spontaneous sarcoma of an adult chicken. It is a replication-defective virus that induces fibrosarcomas in young chickens and oncogenic transformation in cultured chick embryo fibroblasts. The ASV-1 genome has been cloned in the lambda gt WES.lambda B vector from closed circular viral DNA extracted from infected cells. The nucleotide sequence of the oncogene insert in the ASV-1 genome has been determined. It is virtually identical to the sequence of the oncogene crk recently discovered in the avian sarcoma virus CT10. ASV-1 and CT10 are two independent retrovirus isolates carrying the crk oncogene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Avian Sarcoma Viruses / genetics*
  • Avian Sarcoma Viruses / isolation & purification
  • Base Sequence
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Chick Embryo
  • Chickens
  • Cloning, Molecular
  • DNA, Circular / genetics
  • Genes, Viral
  • Genetic Vectors
  • Molecular Sequence Data
  • Oncogene Protein v-crk
  • Oncogenes*
  • Restriction Mapping
  • Retroviridae Proteins, Oncogenic / genetics
  • Sequence Homology, Nucleic Acid


  • DNA, Circular
  • Oncogene Protein v-crk
  • Retroviridae Proteins, Oncogenic