Is intra-articular hyaluronic acid effective in treating osteoarthritis of the hip joint?

J Arthroplasty. 2015 Mar;30(3):507-11. doi: 10.1016/j.arth.2013.10.019. Epub 2013 Nov 8.


Hyaluronic acid (HA) injections are used to treat osteoarthritis of the hip but their efficacy has not been clearly established. The purpose of this meta-analysis was to determine the effect of HA injections on hip pain. There were twenty-three studies that met our criteria and the mean decrease in visual analog scores (VAS) was -1.97 (95% CL, 2.83 to -1.12, P<0.0001). However, the clinical relevance of this change is difficult to determine since the decrease in VAS was only -0.27 in the six randomized trials in the study and the duration of follow-up in most studies was less than six months. Multicenter randomized trials are needed to determine the true efficacy of HA injections in decreasing pain associated with hip osteoarthritis.

Keywords: Synvisc; hip; hyaluronic acid; injection; osteoarthritis.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Hip Joint*
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Injections, Intra-Articular
  • Osteoarthritis, Hip / drug therapy*
  • Treatment Outcome
  • Viscosupplements / administration & dosage*


  • Viscosupplements
  • Hyaluronic Acid