Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 6 (12), 992-1009

Long Noncoding RNAs(lncRNAs) and the Molecular Hallmarks of Aging

Affiliations
Review

Long Noncoding RNAs(lncRNAs) and the Molecular Hallmarks of Aging

Ioannis Grammatikakis et al. Aging (Albany NY).

Abstract

During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes. Here, we review our current understanding of lncRNAs that control the development of aging traits.

Conflict of interest statement

Conflict of interest statement

The authors of this manuscript have no conflict of interests to declare.

Figures

Figure 1
Figure 1. Schematic representation of lncRNAs affecting six major molecular traits of aging
The lncRNAs indicated have been implicated in controlling telomere length, epigenetic gene expression, proteostasis, the pool of stem cells, cell proliferation and senescence, and communication among cells.

Similar articles

  • Mechanistic Links Between Aging and Lung Fibrosis
    VJ Thannickal. Biogerontology 14 (6), 609-15. PMID 23929205. - Review
    Our understanding of the biology of aging has advanced significantly in recent years. This has resulted in the recent formulation of the "hallmarks of aging" that include …
  • The Hallmarks of Aging
    C López-Otín et al. Cell 153 (6), 1194-217. PMID 23746838. - Review
    Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the prim …
  • Mitotic Dysfunction Associated With Aging Hallmarks
    JC Macedo et al. Adv Exp Med Biol 1002, 153-188. PMID 28600786. - Review
    Aging is a biological process characterized by the progressive deterioration of physiological functions known to be the main risk factor for chronic diseases and declinin …
  • The Master Switchers in the Aging of Cardiovascular System, Reverse Senescence by microRNA Signatures; As Highly Conserved Molecules
    F Pourrajab et al. Prog Biophys Mol Biol 119 (2), 111-28. PMID 26033200. - Review
    The incidence of CVD increases with aging, because of long-term exposure to risk factors/stressors. Aging is a complex biological process resulting in progressive loss of …
  • Molecular and Biological Hallmarks of Ageing
    JR Aunan et al. Br J Surg 103 (2), e29-46. PMID 26771470. - Review
    The sum of these molecular hallmarks produces the clinical picture of the elderly surgical patient: frailty, sarcopenia, anaemia, poor nutrition and a blunted immune resp …
See all similar articles

Cited by 56 PubMed Central articles

See all "Cited by" articles

References

    1. López-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153:1194–1217. - PMC - PubMed
    1. Rufini A, Tucci P, Celardo I, Melino G. Senescence and aging: the critical roles of p53. Oncogene. 2013;32:5129–5143. - PubMed
    1. Wang WG. Regulatory RNA-binding proteins in senescence. Ageing Res Rev. 2012;11:485–490. - PubMed
    1. Wu G, Wang D, Huang Y, Han JD. The research progress of microRNAs in aging. Prog Biochem Biophys. 2014;41:273–287.
    1. Yoon JH, Abdelmohsen K, Gorospe M. Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol. 2013;425:3723–3730. - PMC - PubMed

Publication types

MeSH terms

Feedback