Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging

Aging (Albany NY). 2014 Dec;6(12):992-1009. doi: 10.18632/aging.100710.


During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes. Here, we review our current understanding of lncRNAs that control the development of aging traits.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Age Factors
  • Aging / genetics*
  • Aging / metabolism
  • Aging / pathology
  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cellular Senescence / genetics
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Genetic Markers
  • Genomic Instability
  • Genotype
  • Humans
  • Phenotype
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • Stem Cells / metabolism
  • Stem Cells / pathology
  • Telomere Homeostasis


  • Cell Cycle Proteins
  • Genetic Markers
  • RNA, Long Noncoding