Role of Chlamydia Trachomatis and Emerging Chlamydia-related Bacteria in Ectopic Pregnancy in Vietnam

Epidemiol Infect. 2015 Sep;143(12):2635-8. doi: 10.1017/S0950268814003616. Epub 2014 Dec 29.

Abstract

In this case-control study, we investigated the seroprevalence and molecular evidence of Chlamydia trachomatis and Waddlia chondrophila in ectopic pregnancies (EP) and uneventful control pregnancies in 343 women from Vietnam. Whereas presence of C. trachomatis IgG was strongly associated with EP [adjusted odds ratio (aOR) 5·41, 95% confidence interval (CI) 2·58-11·32], its DNA remained undetected in all tubal lesions. We confirmed an independent association between antibodies against Waddlia and previous miscarriage (aOR 1·87, 95% CI 1·02-3·42). Further investigations are needed to understand the clinical significance of Waddlia's high seroprevalence (25·9% in control pregnancies) in this urban population.

Keywords: Adverse pregnancy outcome; Chlamydia-related bacteria; ectopic pregnancy; genital tract infection; intracellular bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Spontaneous / blood
  • Adult
  • Antibodies, Bacterial / blood*
  • Case-Control Studies
  • Chlamydia Infections / blood
  • Chlamydia Infections / epidemiology
  • Chlamydia Infections / microbiology*
  • Chlamydia trachomatis / immunology*
  • Chlamydia trachomatis / isolation & purification
  • Chlamydiales / immunology
  • Chlamydiales / isolation & purification
  • DNA, Bacterial / analysis
  • Fallopian Tubes / chemistry
  • Fallopian Tubes / microbiology
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Placenta / chemistry
  • Placenta / microbiology
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology
  • Pregnancy Complications, Infectious / microbiology
  • Pregnancy, Ectopic / blood
  • Pregnancy, Ectopic / epidemiology
  • Pregnancy, Ectopic / microbiology*
  • Seroepidemiologic Studies
  • Vietnam / epidemiology
  • Young Adult

Substances

  • Antibodies, Bacterial
  • DNA, Bacterial
  • Immunoglobulin G