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Review
. 2014 Dec;19 Suppl 1:57-67; quiz 54-7, 68.
doi: 10.1017/S1092852914000613.

Modulating the Serotonin System in the Treatment of Major Depressive Disorder

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Review

Modulating the Serotonin System in the Treatment of Major Depressive Disorder

Debbi Ann Morrissette et al. CNS Spectr. .

Erratum in

Abstract

Discuss the theory of modulation of receptor activity or the blockade of the reuptake of multiple neurotransmitter systems for the future treatment of MDD. Major depressive disorder (MDD) is a serious and often crippling psychiatric illness with a high risk of relapse and treatment resistance. In this article, we discuss the role of the serotonergic system in MDD including our current understanding of how various serotonin (5HT) receptors modulate monoamine neurotransmission and behavior. We also discuss how pharmacologic interventions, including novel and existing antidepressants and atypical antipsychotics, may be utilized to adjust serotonergic neurotransmission and provide more effective treatments for patients with MDD.

Keywords: SERT; atypical antipsychotic; serotonin; vilazodone; vortioxetine.

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