Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations

Reprod Toxicol. 2015 Jul;54:141-7. doi: 10.1016/j.reprotox.2014.12.015. Epub 2014 Dec 27.

Abstract

Breast cancer incidence continues to increase in the US and Europe, a reflection of the growing influence of environment factors that interact with personal genetics. The US Environmental Protection Agency estimates that there are approximately 10,000 endocrine disrupting chemicals among the common daily exposures that could affect the risk of disease. The daunting tasks of identifying, characterizing, and elucidating the mechanisms of endocrine disrupting chemicals in breast cancer need to be addressed to produce a comprehensive model that will facilitate preventive strategies and public policy. An expert panel met to describe and bring attention to needs linking common environmental exposures, critical windows of exposure, and optimal times of assessment in investigating breast cancer risk. The group included investigators with extensive experience in the use of rodent models and in leading population studies and produced a set of recommendations for effective approaches to gaining insights into the environmental origins of breast cancer across the lifespan.

Keywords: Breast cancer; Endocrine disrupting chemicals; Mammary gland biology; Windows of susceptibility.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Age Factors
  • Animals
  • Biomedical Research / methods*
  • Breast Neoplasms / chemically induced*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Carcinogens, Environmental / toxicity*
  • Cell Transformation, Neoplastic / chemically induced
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology
  • Disease Susceptibility
  • Endocrine Disruptors / toxicity*
  • Environmental Exposure / adverse effects
  • Female
  • Humans
  • Mammary Glands, Animal / drug effects*
  • Mammary Glands, Animal / growth & development
  • Mammary Glands, Animal / metabolism
  • Mammary Glands, Animal / pathology
  • Mammary Glands, Human / drug effects*
  • Mammary Glands, Human / growth & development
  • Mammary Glands, Human / metabolism
  • Mammary Glands, Human / pathology
  • Research Design*
  • Risk Assessment
  • Risk Factors
  • Sexual Development
  • Time Factors

Substances

  • Carcinogens, Environmental
  • Endocrine Disruptors