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. 2015 Jan 1;372(1):78-89.
doi: 10.1056/NEJMsr1407164.

Atypical Hyperplasia of the Breast--Risk Assessment and Management Options

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Free PMC article

Atypical Hyperplasia of the Breast--Risk Assessment and Management Options

Lynn C Hartmann et al. N Engl J Med. .
Free PMC article

Figures

Figure 1
Figure 1. Microanatomical Features of the Breast and Histologic Features of Atypical Hyperplasia
Panel A shows atypical ductal hyperplasia with a proliferation of monotonous cells in architecturally complex patterns, including secondary lumens and micropapillary formations (reproduced from Hartmann et al.). Panel B shows atypical lobular hyperplasia, with expanded acini filled with monotonous polygonal cells and a loss of acinar lumens. Panel C shows multifocal atypical hyperplasia (in this case, atypical lobular hyperplasia). Atypical lobular hyperplasia is present in more than one terminal duct lobular unit, which are clearly separated from one another by interlobular mammary stroma (arrows). Panel D is an illustration of the microanatomy of the breast, including a photomicrograph of a terminal duct lobular unit.
Figure 2
Figure 2. Cumulative Incidence of Breast Cancer after a Diagnosis of Atypical Hyperplasia
Shown is the cumulative incidence of breast cancer (invasive and ductal carcinoma in situ) after a diagnosis of atypical hyperplasia in the Mayo Clinic cohort (Panel A) and in the same cohort stratified according to the number of foci of atypical hyperplasia (Panel B). The dashed lines in Panel A denote 95% confidence intervals.

Comment in

  • Atypical hyperplasia of the breast.
    Hartmann LC, Degnim AC, Dupont WD. Hartmann LC, et al. N Engl J Med. 2015 Mar 26;372(13):1271-2. doi: 10.1056/NEJMc1501046. N Engl J Med. 2015. PMID: 25806929 No abstract available.
  • Atypical hyperplasia of the breast.
    Brentnall AR, Cuzick J. Brentnall AR, et al. N Engl J Med. 2015 Mar 26;372(13):1269-70. doi: 10.1056/NEJMc1501046. N Engl J Med. 2015. PMID: 25806930 No abstract available.
  • Atypical hyperplasia of the breast.
    Reimers LL, Crew KD, Terry MB. Reimers LL, et al. N Engl J Med. 2015 Mar 26;372(13):1270-1. doi: 10.1056/NEJMc1501046. N Engl J Med. 2015. PMID: 25806931 No abstract available.

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