Influence of Morphology and Hemodynamic Factors on Rupture of Multiple Intracranial Aneurysms: Matched-Pairs of Ruptured-Unruptured Aneurysms Located Unilaterally on the Anterior Circulation

BMC Neurol. 2014 Dec 31;14:253. doi: 10.1186/s12883-014-0253-5.

Abstract

Background: The authors evaluated the impact of morphological and hemodynamic factors on the rupture of matched-pairs of ruptured-unruptured intracranial aneurysms on one patient's ipsilateral anterior circulation with 3D reconstruction model and computational fluid dynamic method simulation.

Methods: 20 patients with intracranial aneurysms pairs on the same-side of anterior circulation but with different rupture status were retrospectively collected. Each pair was divided into ruptured-unruptured group. Patient-specific models based on their 3D-DSA images were constructed and analyzed. The relative locations, morphologic and hemodynamic factors of these two groups were compared.

Results: There was no significant difference in the relative bleeding location. The morphological factors analysis found that the ruptured aneurysms more often had irregular shape and had significantly higher maximum height and aspect ratio. The hemodynamic factors analysis found lower minimum wall shear stress (WSSmin) and more low-wall shear stress-area (LSA) in the ruptured aneurysms than that of the unruptured ones. The ruptured aneurysms more often had WSSmin on the dome.

Conclusions: Intracranial aneurysms pairs with different rupture status on unilateral side of anterior circulation may be a good disease model to investigate possible characteristics linked to rupture independent of patient characteristics. Irregular shape, larger size, higher aspect ratio, lower WSSmin and more LSA may indicate a higher risk for their rupture.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aneurysm, Ruptured / pathology*
  • Aneurysm, Ruptured / physiopathology
  • Angiography, Digital Subtraction / methods
  • Biomechanical Phenomena
  • Case-Control Studies
  • Cerebral Angiography / methods
  • Cerebral Arteries / pathology*
  • Cerebral Arteries / physiopathology
  • Cerebrovascular Circulation / physiology
  • Female
  • Hemodynamics / physiology*
  • Hemorheology / physiology
  • Humans
  • Hydrodynamics
  • Image Processing, Computer-Assisted / methods
  • Imaging, Three-Dimensional / methods
  • Intracranial Aneurysm / pathology*
  • Intracranial Aneurysm / physiopathology
  • Male
  • Middle Aged
  • Models, Cardiovascular
  • Patient-Specific Modeling
  • Retrospective Studies
  • Risk Factors
  • Stress, Mechanical