Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

Turk J Med Sci. 2014;44(6):980-4. doi: 10.3906/sag-1311-88.


Background/aim: To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease.

Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population.

Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group.

Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

MeSH terms

  • Adult
  • C-Reactive Protein / analysis*
  • Cardiovascular Diseases / epidemiology*
  • Female
  • Humans
  • Lipids / blood
  • Mean Platelet Volume*
  • Middle Aged
  • Postmenopause
  • Retrospective Studies
  • Risk Assessment


  • Lipids
  • C-Reactive Protein