mTOR signaling in cellular and organismal energetics

Curr Opin Cell Biol. 2015 Apr;33:55-66. doi: 10.1016/j.ceb.2014.12.001. Epub 2014 Dec 31.

Abstract

Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can also affect other organs thereby affecting whole body metabolism and energy homeostasis in a non-cell autonomous manner. It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders, such as obesity, diabetes and cancer. This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / enzymology
  • Adipose Tissue / metabolism
  • Animals
  • Energy Metabolism*
  • Homeostasis
  • Humans
  • Hypothalamus / enzymology
  • Hypothalamus / metabolism
  • Liver / enzymology
  • Liver / metabolism
  • Metabolic Diseases / enzymology
  • Metabolic Diseases / metabolism
  • Mitochondria / enzymology
  • Mitochondria / metabolism
  • Muscle, Skeletal / enzymology
  • Muscle, Skeletal / metabolism
  • Nucleotides / biosynthesis
  • Protein Biosynthesis
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • Nucleotides
  • TOR Serine-Threonine Kinases