Cellular stress response cross talk maintains protein and energy homeostasis

EMBO J. 2015 Feb 3;34(3):267-9. doi: 10.15252/embj.201490757. Epub 2015 Jan 2.


Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both environmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 (HSF1), the primary regulator of the proteotoxic stress response, and AMP-activated protein kinase (AMPK), the primary sensor in the metabolic stress response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Animals
  • DNA-Binding Proteins / metabolism*
  • Heat Shock Transcription Factors
  • Neoplasm Proteins / metabolism*
  • Neoplasms, Experimental / metabolism*
  • Stress, Physiological*
  • Transcription Factors / metabolism*


  • DNA-Binding Proteins
  • Heat Shock Transcription Factors
  • Hsf1 protein, mouse
  • Neoplasm Proteins
  • Transcription Factors
  • AMP-Activated Protein Kinases