Cellular stress response cross talk maintains protein and energy homeostasis

Cynthia L Swan; Lea Sistonen

doi:10.15252/embj.201490757

Cellular stress response cross talk maintains protein and energy homeostasis

EMBO J. 2015 Feb 3;34(3):267-9. doi: 10.15252/embj.201490757. Epub 2015 Jan 2.

Authors

Cynthia L Swan¹, Lea Sistonen¹

Affiliation

¹ Department of Biosciences, Åbo Akademi University, Turku, Finland Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

Abstract

Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both environmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 (HSF1), the primary regulator of the proteotoxic stress response, and AMP-activated protein kinase (AMPK), the primary sensor in the metabolic stress response.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

AMP-Activated Protein Kinases / metabolism*
Animals
DNA-Binding Proteins / metabolism*
Heat Shock Transcription Factors
Neoplasm Proteins / metabolism*
Neoplasms, Experimental / metabolism*
Stress, Physiological*
Transcription Factors / metabolism*

Substances

DNA-Binding Proteins
Heat Shock Transcription Factors
Hsf1 protein, mouse
Neoplasm Proteins
Transcription Factors
AMP-Activated Protein Kinases