No effect of proton pump inhibitors on crying and irritability in infants: systematic review of randomized controlled trials

J Pediatr. 2015 Mar;166(3):767-70.e3. doi: 10.1016/j.jpeds.2014.11.030. Epub 2014 Dec 30.


Proton pump inhibitors are increasingly being used to treat infants with crying and/or irritability based on the assumption that these symptoms are attributable to gastroesophageal reflux. However, the data from a systematic review of randomized controlled trials do not support the use of proton pump inhibitors to decrease infant crying and irritability.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Crying / psychology*
  • Emotions / physiology*
  • Gastroesophageal Reflux / drug therapy*
  • Gastroesophageal Reflux / psychology
  • Humans
  • Infant
  • Irritable Mood / drug effects*
  • Proton Pump Inhibitors / therapeutic use*
  • Randomized Controlled Trials as Topic*


  • Proton Pump Inhibitors