Efficacy of Bifidobacterium tetragenous viable bacteria tablets for cancer patients with functional constipation

Asian Pac J Cancer Prev. 2014;15(23):10241-4. doi: 10.7314/apjcp.2014.15.23.10241.

Abstract

Objective: To investigate the efficacy and side effects of Bifidobacterium tetragenous viable bacteria tablets in treating cancer patients with functional constipation during chemotherapy.

Methods: A consecutive cohort of 100 cancer patients with functional constipation were divided into two equal groups: patients in the experimental group were given Bifidobacterium tetragenous viable bacteria tablets combined with chemotherapy, while patients in the control group received chemotherapy alone. After 4 weeks, the efficacy and side effects in treating functional constipation were evaluated.

Results: Constipation in 48 patients in experimental group was controlled (9 returned to normal), with a total response rate of 96%, and 1 patient reported diarrhea (2%). In contrast only 16 patients in the control group demonstrated improvement and 34 were still constipated after chemotherapy, with a response rate of 32%. The difference in response rate was statistically significant (P <0.05).

Conclusion: This study suggested that Bifidobacterium tetragenous viable bacteria tablets are effective and safe in treating cancer patients with functional constipation during chemotherapy.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Bifidobacterium*
  • Colorectal Neoplasms / complications
  • Colorectal Neoplasms / drug therapy*
  • Constipation / complications
  • Constipation / therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Probiotics / therapeutic use*
  • Stomach Neoplasms / complications
  • Stomach Neoplasms / drug therapy*
  • Treatment Outcome

Substances

  • Antineoplastic Agents